STANDARD OPERATING PROCEDURE Title: VIAL WASHING

1. Purpose
It is established to provide a standard procedure for “Vial Washing”.
1 Scope
It is applicable to injection section.
2 Responsibilities
1. Production Pharmacist
2. Supervisor
3. Worker
3 Procedure
Vial washing is done in two steps
1. Pre-washing
2. Final washing

1. Pre- Washing
a) Wear the mask and cover the hair properly with cap.
b) Stack the vial cartons received from store on the clean pallet in de-cartoning area.
c) Wash thoroughly the sinks of washing station and drain out any dirty water.
d) Fill the sinks of washing stations up to half with tap water.
e) In sink-1,add one bottle of liquid hands to make lather.
f) Pick up one carton of vial from de-cartoning area, remove its secondary packing, and dip the vials in the sink. Discard primary packing in the dust bin kept for this purpose in de-cartoning area.
g) Add to the 2-3 vials cartons similarly.
h) Brush each of the vial in sink with nylon material from in and outside.
i) Transfer each of the brushed vial in sink-2.
j) In sink-2 give the vial individually a rinse of tap water by filling the vials with water in the sink and emptying in the same sink.
k) Rinse each of the vial two times in this way and drop into the sink -3.
l) In sink-3, process of rinsing is repeated and the vials are arranged in the washed SS trays.
m) In the trays vials are placed with their neck downward These vials rare ready for final washing
n) Cycle of washing from Sink-1 to Sink-3 is repeated for whole of batch.
o) Water in each of the three sinks is changed with fresh one after it gets dirty.
2. Final washing
a) Give the pre-washed a final washing on the “ vial washing machine” following the Standard Operating Procedure for “Vial Washing Machine(GL/SOP/M/078)”